A Study may slow down the growth of head and neck cancer

 Head & neck cancer

Head and neck cancer  – new research eases back the development of tumors.

A group lead by UCLA School of Dentistry is getting closer to finding a more efficient treatment that could treat head and neck cancer. According to the study by aiming a weakness in the cellular progression of cancer replication, they could alter its reaction to immunotherapy.

The forecast for head and neck cancer is bad, with a high five-year mortality rate.

They concentrated on the enzyme called KDM4A. The duplication and propagation of cancer cells is associated with an over-expression of the enzyme.

Fight infection

By eliminating the enzyme in a few mice, the scientists observed a considerable decline in the spreading of cancer to the lymph nodes. Which in turn could be a sign of metastasis of cancer in the body. The removal of the enzyme also led to stimulation of immunity in the form of  T cells and aided to increase natural cancer resistance.

Additionally, they then launched a PD-1 blockade, which heralds immunotherapy drugs to raid cancer cells. The combination of immunotherapy and KDM4A elimination further slowed down cell cancer growth and lymph node metastasis.

‘Major inferences’

Dr. Cun-Yu Wang – who led the group – said: ‘We know that the KDM4A gene plays a critical role in cancer cell replication and spread.

‘So we focused our study on removing this gene to see if we would get an opposite response.’

Dr. Paul Krebsbach – dean and professor at the UCLA School of Dentistry – considers the discoveries have ‘key consequences’ for the potential of life-saving treatments.

‘I am continuously impressed by Dr. Cun-Yu Wang and his team for breaking through barriers in our understanding of cancer-causing cellular processes,’ said Dr. Paul Krebsbach.

The consequences of this investigation have significant ramifications for the improvement of more viable, life-saving cancer treatments.

Dr Pascal Terjanian man in suite

Dr. Pascal Terjanian

 

Follow Dr. Pascal Terjanian blog and social media to keep up with all the latest dental news and trends.

 

 

 

 

Sources

https://www.cancer.gov/types/head-and-neck/head-neck-fact-sheet

https://www.news-medical.net/news/20210324/Study-may-lead-to-more-refined-approaches-for-head-and-neck-cancers.aspx

 

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